Elevation of p11 in lateral habenula mediates depression-like behavior
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چکیده
منابع مشابه
Elevation of p11 in Lateral Habenula Mediates Depression-Like Behavior
The lateral habenula (LHb) is a key brain region involved in the pathophysiology of depression. It is activated by stimuli associated with negative experiences and is involved in encoding aversive signals. Hyperactivity of LHb is found in both rodent models of depression and human patients with depression. However, little is known about the underlying molecular mechanisms. Here we show that in ...
متن کاملβCaMKII in lateral habenula mediates core symptoms of depression.
The lateral habenula (LHb) has recently emerged as a key brain region in the pathophysiology of depression. However, the molecular mechanism by which LHb becomes hyperactive in depression remains unknown. Through a quantitative proteomic screen, we found that expression of the β form of calcium/calmodulin-dependent protein kinase type II (βCaMΚΙΙ) was significantly up-regulated in the LHb of an...
متن کاملLateral habenula in the pathophysiology of depression
Depression is a devastating disorder with a combination of diverse symptoms such as low self-esteem, lack of motivation, anhedonia, loss of appetite, low energy, and discomfort without a clear cause. Depression has been suggested to be the result of maladaptive changes in specific brain circuits. Recently, the lateral habenula (LHb) has emerged as a key brain region in the pathophysiology of de...
متن کاملRole of the Lateral Habenula in Pain-Associated Depression
Patients with chronic pain have significantly higher incidences of depression and anxiety than the average person. However, the mechanism underlying this link has not been elucidated in terms of how chronic pain causes significant mood changes and further develops into severe anxiety or depression. The serotonergic system in the raphe nuclei is an important component in both pain processing and...
متن کاملMolecular Profiling of the Lateral Habenula in a Rat Model of Depression
OBJECTIVE This study systematically investigated the effect of chronic mild stress and response to antidepressant treatment in the lateral habenula at the whole genome level. METHODS Rat whole genome expression chips (Affymetrix) were used to detect gene expression regulations in the lateral habenula of rats subjected to chronic mild stress (mild stressors exchanged twice a day for 8 weeks). ...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2017
ISSN: 1359-4184,1476-5578
DOI: 10.1038/mp.2017.96